BNCT
Boron Neutron Capture Therapy (BNCT) is a form of radiation therapy that uses heavy ions produced by nuclear reactions between neutrons and boron elements within tumors to destroy cancer cells.
Cell-Level Targeted Radiotherapy
BNCT is a unique type of radiation therapy that enables targeting of cancer at the cellular level.
Cell Level: Treatment for Cells
Cancer treatment is upgraded to the cellular level, achieving precise attack on every cancer cell.
Targeting: boron drug locates cancer cells
By targeting drugs carrying boron-10 atoms, they can accumulate and lock on to cancer cell, forming targeted localization.
Radiotherapy: a simple and effective physical therapy method
Based on physical effects, combined with targeted positioning, radiotherapy becomes simpler, more precise, and more efficient.
History
In 1936, Gorden.L.Locher proposed the concept of Boron Neutron Capture Therapy (BNCT), which laid the foundation for BNCT.
In 1951, William Sweet's team conducted the world's first human clinical research on BNCT, marking the transition of BNCT from theory to practice.
After 2010, with the development of proton accelerator technology, BNCT made significant breakthroughs. During the same period,compact accelerator based neutron sources have been developed utilizing a variety of different accelerator technologies,laying the foundation for further development of BNCT.
In 2020, the approvals received in Japan of an AB-BNCT system, dose calculation engine and treatment planning system together with a boron pharmaceutical for treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck under public health insurance has brought interest around the world in implementing similar facilities.
To date, countries including China, Japan, South Korea, Russia, Italy, Argentina, etc. are accelerating the research and development of BNCT and promoting its further development.
The Advantages of BNCT
- The reaction of a neutron and boron destroys cancer cells selectively.
- Utilizes low-energy thermal neutrons that inflict minimal damage to healthy cells.
- Efcacious for invasive cancer, rapidly spreading cancer.
- Short treatment period (number of irradiations: 1-2, 30-60 min./time.)
- Since an operation is unnecessary, it contributes to a patient's QOL.
- Not using anti-cancer drugs eliminates the occurrence of side effects.
Frontier
2023/08/14
Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies
Andrea Monti Hughes，Naonori Hu. 14 August 2023
2023/08/11
A Review of Planned, Ongoing Clinical Studies and Recent Development of BNCT in Mainland of China
Cancers 2023, 15(16),4060; 11 August 2023. Zizhu Zhang, Yizheng Chong, Yuanhao Liu, Jianji Pan, Cheng Huang, Qi Sun, Zhibo Liu, Xiayang Zhu, Yujun Shao, Congjun Jin and Tong Liu
2023/08/01
頭頸部癌の新たな治療戦略 ―ホウ素中性子捕捉療法―
ホウ素中性子捕獲療法（Boron Neutron Capture Therapy : BNCT）は，ホウ素中性子捕捉反応から生じる粒子線を利用する粒子線治療であり，癌組織に集積 したホウ素と熱中性子との核反応で生じる高 LET 放射線により癌細胞を選択的 に破壊することが可能で，放射線低感受性の固形癌にも高い抗腫瘍効果が期待で きる．近年中性子発生源として BNCT 専用加速器の開発が進み，本...
2023/02/20
Introduction to the Monte Carlo dose engine COMPASS for BNCT
Wan-Bing Zhong, Jiang Chen, Yi-Chiao Teng & Yuan-Hao Liu; Scientific Reports volume 13, Article number: 11965 (2023)
2022/12/31
Boron Neutron Capture Therapy: History and recent advances
31 December 2022. Mahima Purohit, Manoj Kumar
2022/03/31
Boron Neutron Capture Therapy: Current Status and Challenges
2022 Mar 31. Song Wang , Zhengchao Zhang , Lele Miao, Yumin Li
2021/12/31
Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
Pablo Torres-Sánchez, Ignacio Porras, Nataliya Ramos-Chernenko, Fernando Arias de Saavedra & Javier Praena. Scientific Reports volume 11, Article number: 7576 (2021)
2021/07/14
Research progress of 10B concentration and distribution measurement in boron neutron capture therapy
2021 Jul 14. Song Gao, Wentian Cao, Xinrui Huang, Shanglian Bao